Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences

Twitter-Link: @TomNGrossmann

For more news, visit us at Twitter:

Article in Communications Biology is online

July 10, 2024

Identification of an H-Ras nanocluster disrupting peptide

CL Steffen, G Manoharan, K Pavic, A Yeste-Vázquez, M Knuuttila, N Arora, Y Zhou, H Härmä, A Gaigneaux, TN Grossmann, DK Abankwa* Commun. Biol. DOI: 10.1038/s42003-024-06523-9

Congrats to the Abankwa group and great to be able to contribute to this study!

Account in Synlett is online

April 17, 2024

From protein structures to functional biomimetics

C Durukan, TN Grossmann Synlett DOI: 10.1055/a-2308-1795

Article in ChemBioChem is online

March 19, 2024

Binding dynamics of a stapled peptide targeting the transcription factor NF-Y

C Durukan, F Arbore, R Klintrot, C Bigiotti, IM Ilie, J Vreede, TN Grossmann*, S Hennig* ChemBioChem DOI: 10.1002/cbic.202400020

Great team effort and congratulations to everyone! Thanks to the MD contribution from our University of Amsterdam colleagues!

Congratulations to Dr. Felix Paulußen!

January 15, 2024

Felix successfully defended his thesis today!
Big thanks to co-promotor Dr. Joen Juirink!

Read more about Felix’ work here: J. Am. Chem. Soc. 2022, 144, 15303–15313

Merry Christmas and enjoy the holidays!

December 20, 2023

Article in Nature Synthesis is online

December 5, 2023

A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins  

M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0

Congrats to the Noël group and great to be part of the team!

Article in Chem (Cell press) is online

November 2, 2023

Covalent Bicyclization of Protein Complexes Yields Durable Quaternary Structures

GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003

Great collaboration with the incircular team!
More information also at the VU news page.

Welcome to Juan Lizandra Pérez!

November 1, 2023

Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!

Happy Halloween 🎃 👻!

October 31, 2023

Welcome to Yun Li!

October 2, 2023

Yun joins our group with support from the Chinese Scholarship Council. Congratulations!

Communication in Angewandte Chemie is online

August 22, 2023

Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA

NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.

Great collaboration with the Brock lab at Radboud University!

AIMMS Festival 2023

July 4, 2023

We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!

Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304

Welcome to Jannik, our new postdoc!

June 14, 2023

Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!

Article in Bioconjugate Chemistry is online

May 29, 2023

Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions

S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151

Great collaboration with the incircular team!

KWF project on Wnt inhibitors

May 5, 2023

The KWF funded project ‘WINCE: Wnt inhibitors to treat colorectal cancer’ (joint with the Vermeulen lab) has started. It’s based on our Wnt inhibitors:

M Wendt et al. Angew. Chem. DOI: 10.1002/anie.202102082
L Dietrich et al. Cell Chem. Biol. DOI: 10.1016/j.chembiol.2017.06.013

Article in Chemical Communications is online

April 19, 2023

Non-enzymatic protein templates amide bond formation and provides catalytic turnover

N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c

ERC proof-of-concept project grabRNA

April 3, 2023

The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:

A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149 
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103

Welcome to our new PhD candidates!

February 1, 2023

Welcome Eni Rile, Marvin Albers and Anissa Haim! Great to have you onboard!

Merry Christmas and enjoy the holidays!

December 18, 2022

Review in Journal of Peptide Science is online

October 24, 2022

Peptide-based covalent inhibitors of protein-protein interactions

FM Paulussen, TN Grossmann, J. Pept. Sci. DOI: 10.1002/psc.3457