Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
Communication in Angewandte Chemie is online
August 22, 2023
‘Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA’
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
AIMMS Festival 2023
July 4, 2023
We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Welcome to Jannik, our new postdoc!
June 14, 2023
Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Article in Bioconjugate Chemistry is online
May 29, 2023
“Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions”
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
Article in Chemical Communications is online
April 19, 2023
“Non-enzymatic protein templates amide bond formation and provides catalytic turnover”
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c
ERC proof-of-concept project grabRNA
April 3, 2023
The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:
A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103
Welcome to our new PhD candidates!
February 1, 2023
Welcome Eni Rile, Marvin Albers and Anissa Haim! Great to have you onboard!
Merry Christmas and enjoy the holidays!December 18, 2022
Review in Journal of Peptide Science is online
October 24, 2022
“Peptide-based covalent inhibitors of protein-protein interactions”
FM Paulussen, TN Grossmann, J. Pept. Sci. DOI: 10.1002/psc.3457
Article in JACS is online
August 12, 2022
“Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex”
FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Congratulations to the entire team at the Vrije Universiteit Amsterdam and Universiteit van Amsterdam! Great collaboration with the groups of Joen Luirink, Tanneke den Blaauwen, Peter van Ulsen, and Daan Geerke.
Review in Bioorg. Med. Chem. is online
July 14, 2022
“Targeting the interaction of ß-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling”
EMR Koelman, A Yeste-Vázquez, TN Grossmann, DOI: 10.1016/j.bmc.2022.116920 – open access (PDF)
Article in Antibiotics is online
February 23, 2022
“Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo”
GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273
Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!
Welcome to our new group members!
February 1, 2022
Great to have Master students Anissa Haim, Jules Bouffard, Tim Lugtenburg, Willem von Meijenfeldt, Léo Romão Soares and Olivier van Zadelhoff, as well as research associate Rasmus Klintrot joining our group.
Article in Nucleic Acids Research is online
December 6, 2021
“Constrained peptides mimic a viral suppressor of RNA silencing”
A Kuepper et al. Nucleic Acids Res., DOI: 10.1093/nar/gkab1149
Congratulations to the entire team at the VU Amsterdam, University Hospital Essen, Radboud University, and the International Institute of Molecular and Cell Biology in Warsaw!