Happy New Year!
January 10, 2025We wish everyone a Happy New Year!! Also, all the best to Alejandro Yeste-Vázquez who’s leaving our group to join the lab of Juan Del Valle at the University of Notre Dame.
Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Twitter:
@TomNGrossmann
Biotech Booster supports our Wnt-targeting efforts
October 17, 2024Congratulations to Felix Paulussen for securing funding by Biotech Booster a Nationaal Groeifonds for developing cancer treatments based on the group’s findings: Yeste-Vázquez et al. Angew Chem 2024 and Wendt et al. Angew Chem 2021.
Big thanks to our technology transfer office IXA for their support!
Article in Angewandte Chemie is online
August 29, 2024Structure-based design of bicyclic helical peptides that target the oncogene β-catenin
A Yeste-Vázquez, FM Paulussen, M Wendt, R Klintrot, C Schulte, K Wallraven, L van Gijzel, B Simeonov, M van der Gaag, A Gerber, HM Maric, S Hennig, TN Grossmann, Angew. Chem. Int. Ed. DOI: 10.1002/anie.202411749
Thanks to the collaborating groups of Hans Maric and Alan Gerber!
European Peptide Symposium 2024
August 29, 2024Our group’s enjoying the European Peptide Symposium in Florence with great talks and posters.
Congratulations to Alejandro for receiving the 2nd prize for the Best Young Investigator Poster Presentation (Dr. Bert and Dr. Elizabetz Shram Award).
Article in Communications Biology is online
July 10, 2024Identification of an H-Ras nanocluster disrupting peptide
CL Steffen, G Manoharan, K Pavic, A Yeste-Vázquez, M Knuuttila, N Arora, Y Zhou, H Härmä, A Gaigneaux, TN Grossmann, DK Abankwa* Commun. Biol. DOI: 10.1038/s42003-024-06523-9
Congrats to the Abankwa group and great to be able to contribute to this study!
Account in Synlett is online
April 17, 2024From protein structures to functional biomimetics
C Durukan, TN Grossmann Synlett DOI: 10.1055/a-2308-1795
Article in ChemBioChem is online
March 19, 2024Binding dynamics of a stapled peptide targeting the transcription factor NF-Y
C Durukan, F Arbore, R Klintrot, C Bigiotti, IM Ilie, J Vreede, TN Grossmann*, S Hennig* ChemBioChem DOI: 10.1002/cbic.202400020
Great team effort and congratulations to everyone! Thanks to the MD contribution from our University of Amsterdam colleagues!
Congratulations to Dr. Felix Paulußen!
January 15, 2024Felix successfully defended his thesis today!
Big thanks to co-promotor Dr. Joen Juirink!
Read more about Felix’ work here: J. Am. Chem. Soc. 2022, 144, 15303–15313
Merry Christmas and enjoy the holidays!
December 20, 2023
Article in Nature Synthesis is online
December 5, 2023A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Article in Chem (Cell press) is online
November 2, 2023Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Great collaboration with the incircular team!
More information also at the VU news page.
Welcome to Juan Lizandra Pérez!
November 1, 2023Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Happy Halloween 🎃 👻!
October 31, 2023
Welcome to Yun Li!
October 2, 2023Yun joins our group with support from the Chinese Scholarship Council. Congratulations!
Communication in Angewandte Chemie is online
August 22, 2023Environment-responsive peptide dimers bind and stabilize double-stranded RNA
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
AIMMS Festival 2023
July 4, 2023We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Welcome to Jannik, our new postdoc!
June 14, 2023Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Article in Bioconjugate Chemistry is online
May 29, 2023Bicyclic engineered Sortase A performs transpeptidation under denaturing conditions
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
Great collaboration with the incircular team!
KWF project on Wnt inhibitors
May 5, 2023The KWF funded project ‘WINCE: Wnt inhibitors to treat colorectal cancer’ (joint with the Vermeulen lab) has started. It’s based on our Wnt inhibitors:
M Wendt et al. Angew. Chem. DOI: 10.1002/anie.202102082
L Dietrich et al. Cell Chem. Biol. DOI: 10.1016/j.chembiol.2017.06.013
Article in Chemical Communications is online
April 19, 2023Non-enzymatic protein templates amide bond formation and provides catalytic turnover
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c