Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
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@TomNGrossmann
A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Covalent Bicyclization of Protein Complexes Yields Durable Quaternary Structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
The KWF funded project ‘WINCE: Wnt inhibitors to treat colorectal cancer’ (joint with the Vermeulen lab) has started. It’s based on our Wnt inhibitors:
M Wendt et al. Angew. Chem. DOI: 10.1002/anie.202102082
L Dietrich et al. Cell Chem. Biol. DOI: 10.1016/j.chembiol.2017.06.013
Non-enzymatic protein templates amide bond formation and provides catalytic turnover
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c
The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:
A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103
Welcome Eni Rile, Marvin Albers and Anissa Haim! Great to have you onboard!
Peptide-based covalent inhibitors of protein-protein interactions
FM Paulussen, TN Grossmann, J. Pept. Sci. DOI: 10.1002/psc.3457
Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex
FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Congratulations to the entire team at the Vrije Universiteit Amsterdam and Universiteit van Amsterdam! Great collaboration with the groups of Joen Luirink, Tanneke den Blaauwen, Peter van Ulsen, and Daan Geerke.
Targeting the interaction of ß-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling
EMR Koelman, A Yeste-Vázquez, TN Grossmann, DOI: 10.1016/j.bmc.2022.116920 – open access (PDF)
We’re very proud to see Nick moving on to Linköping University in Sweden. Congratulations Nick!!!
Read more here: https://www.scilifelab.se/news/new-ddls-fellow-nicholas-pearce
Nick’s homepage: https://macromolecular.github.io
Tom is now member of the Editorial Advisory Board of the Journal of Peptide Science, the official journal of the European Peptide Society.
Niall successfully defended his thesis today!
Read more about his work here: McLoughlin et al., Chem. Eur. J. 2021
Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo
GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273
Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!
