Congratulations to Dr. Niall McLoughlin!
March 28, 2022Niall successfully defended his thesis today!
Read more about his work here: McLoughlin et al., Chem. Eur. J. 2021
Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Twitter:
@TomNGrossmann
Article in Antibiotics is online
February 23, 2022“Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo”
GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273
Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!
ERC Proof-of-Concept grant
February 10, 2022Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts towards novel inhibitors of oncogenic Wnt signalling.
Read more here: Wendt et al., Angew. Chem. 2021
Welcome to our new group members!
February 1, 2022Great to have Master students Anissa Haim, Jules Bouffard, Tim Lugtenburg, Willem von Meijenfeldt, Léo Romão Soares and Olivier van Zadelhoff, as well as research associate Rasmus Klintrot joining our group.
EIC transition grant for incircular
January 28, 2022The spin-off company incircular BV has been selected for the EIC Transition grant for utilizing our INCYPRO protein stabilization technology. Congratulations to Saskia and the entire incircular team!
Read more about INCYPRO here: Neubacher et al., J. Org. Chem. 2020 and Pelay‑Gimeno et al., Angew. Chem. 2018
Article in Nucleic Acids Research is online
December 6, 2021“Constrained peptides mimic a viral suppressor of RNA silencing”
A Kuepper et al. Nucleic Acids Res., DOI: 10.1093/nar/gkab1149
Congratulations to the entire team at the VU Amsterdam, University Hospital Essen, Radboud University, and the International Institute of Molecular and Cell Biology in Warsaw!
Congratulations to Dr. Sebastian Kiehstaller and Dr. Mathias Wendt!
November 30, 2021Sebastian and Mathias successfully defended their PhDs!
Read more about their work here: Kiehstaller et al., J. Biol. Chem. 2020 and Wendt et al., Angew. Chem. 2021
New ChemBioChem Editorial Advisory Board member
October 11, 2021Tom is now member of the Editorial Advisory Board of ChemBioChem joining a great team of Chemical Biology colleagues:
https://chemistry-europe.onlinelibrary.wiley.com/hub/journal/14397633/editorial-board
Article featured as Angewandte Chemie back cover
June 11, 2021Our article “Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling” DOI: 10.1002/anie.202102082 has been featured as back cover at Angewandte Chemie. Thanks to first author Mathias for the great cover design!
Review in ChemBioChem is online
June 1, 2021“Protein Macrocyclization for Tertiary Structure Stabilization”
A Haim, S Neubacher, TN Grossmann DOI: 10.1002/cbic.202100111 – open access (PDF)
Article in Chem. Eur. J. is online
May 20, 2021“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”
NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)
Article in Angewandte Chemie is online
March 30, 2021“Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling”
M Wendt et al. DOI: 10.1002/anie.202102082 – open access (PDF)
This has been a great team effort – thanks to everyone involved!
University spin-off incircular has been formed
February 15, 2021We are happy to announce the incorporation of incircular BV, a university spin-off utilizing our INCYPRO protein stabilization technology. Big thanks to all involved researchers and for support by the European Research Council, the Innovation Exchange Amsterdam, the Demonstrator Lab and the Dutch Research Council.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018
Book chapter on stapled peptides is now available
December 10, 2020Our book chapter “Stapled Peptide Inhibitors of Protein-Protein Interactions” in “Inhibitors of Protein-Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.
Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!
Article in Nature Communications is online
October 27, 2020“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”
H Adihou et al. Nature Commun., 11, 5425 (2020)
Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel
Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez
October 10, 2020It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!
Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant
July 4, 2020Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018
Welcome to Ivana Drienovská
July 1, 2020Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska
Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper
July 1, 2020Great to have Mohamed and Glenn joining our INCYPRO team!
CORDIS features our INCYPRO technology
June 28, 2020The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology: https://t.co/j5ZGsnU6Mm?amp=1
We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!