Institute of Organic and Biomolecular Chemistry
Faculty of Chemistry
Georg-August-Universität Göttingen
For more news, visit us at Bluesky:
@TomNGrossmann
Chemical reactions for the ligand-directed modification of native proteins
A Haim, CJ Henderson, M Akdeniz, T Noël, TN Grossmann, Chem. Soc. Rev. DOI: 10.1039/d6cs00702c
We’re happy to see a massive collaborative effort with the Noël group resulting in this great tutorial review!
FlexCAT aims to develop innovative strategies to study and target intrinsically disordered regions (IDR) in proteins, and there are two open PhD candidate positions in our lab:
1) Structure-based design of peptide-derived β-catenin inhibitors (DC #9)
2) Semi-synthesis of modified β-catenin proteins (DC #10)
Read more about the application procedure here (PDF) and apply here: https://phd-recruiting.medunigraz.at/ (Application deadline: October 31, 2026)
Remote residue substitution and macrocyclization preorganize a β-hairpin peptide and enhance β-catenin binding
Congratulations to Sabine Schacht on 25 years at Georg August University Göttingen! It was wonderful to celebrate this special occasion together with Prof. Lutz Tietze, whose research group Sabine first joined at our institute.
Waldemar joins us from Norbert Sewald’s group starting as postdoc, and Constantin returns after completing his MSc project with us. Both will work on peptidomimetics addressing challenging protein targets.
Thanks to the organisers for the exciting event (PTF 2026)! Congratulations to Elena Controneo for the winning the Best Contributed Talk Prize!
Janina did her MSc project in the lab of Kai Tittmann and now started her PhD research on the INCYPRO-stabilization of enzymes in our group.
Great to participate in the 17th German Peptide Symposium at the University of Duisburg-Essen. We’re happy about the opportunity to present our research. Congratulations to Anissa Haim and Ana Alcalde Ordonez for their poster awards!
TAV2b peptide derivatives underwind and stabilize dsRNA upon binding
ZM Rashid, M Klein, T van Heesch, S Quack, Q Smitskamp, PPB America, P Rivas, MA Albers, J Paulus, J Vreede, TN Grossmann, D Dulin, J. Am. Chem. Soc. DOI: 10.1021/jacs.5c18586
Great to see what our peptides do to RNA. Congrats to the Dulin group and their amazing magnetic tweezers! Read more about our RNA binders here McLoughlin et al. Angew. Chem. 2023 and Kuepper et al. Nucleic Acids Res. 2021
Melina joins our group in Göttingen as lab technician. Moritz did his MSc research with the Simeth-Crespi group and just started his PhD research on innovative approaches towards novel proteomimetics.
Stabilizing proteins by chemical cross-linking: Insights into conformation, unfolding, and aggregation using native ion mobility mass spectrometry
Our group attended the Polish Peptide Symposium with great talks and posters. Thanks to the organisers for the exciting event! Congratulations to Felix Paulußen for winning the Award for the Best Poster Presentation.
After nearly a decade at the Vrije Universiteit Amsterdam, Tom is starting a new position at the University of Göttingen. A big THANK YOU to everyone in the group who supported our research and teaching activities throughout the years!!
Helicity-Dependent Enzymatic Peptide Cyclisation
C Durukan, J Faierson, I van der Wal, J Lizandra Pérez, S Hennig, TN Grossmann
J. Pept. Sci. DOI: 10.1002/psc.70024
Big congrats to Juan for being awarded a Marie Skłodowska-Curie postdoc fellowship by the European Union! It is great to have Juan pursue his work on the design of proteomimetic scaffolds with enhanced biological function, such as inhibitors for the oncogene β-catenin.
Health~Holland supports our initiative of modulating Galectins using INCYPRO (LSHM24021) via a Public-Private Partnership Allowance. We’re looking forward to work together with Dr. Victor Thijssen (Amsterdam UMC) and the Incircular team.
Powered by Health~Holland, Top Sector Life Sciences & Health.
We wish everyone a Happy New Year!! Also, all the best to Alejandro Yeste-Vázquez who’s leaving our group to join the lab of Juan Del Valle at the University of Notre Dame.
Congratulations to Felix Paulussen for securing funding by Biotech Booster a Nationaal Groeifonds for developing cancer treatments based on the group’s findings: Yeste-Vázquez et al. Angew Chem 2024 and Wendt et al. Angew Chem 2021.
Big thanks to our technology transfer office IXA for their support!
Structure-based design of bicyclic helical peptides that target the oncogene β-catenin
A Yeste-Vázquez, FM Paulussen, M Wendt, R Klintrot, C Schulte, K Wallraven, L van Gijzel, B Simeonov, M van der Gaag, A Gerber, HM Maric, S Hennig, TN Grossmann, Angew. Chem. Int. Ed. DOI: 10.1002/anie.202411749
Thanks to the collaborating groups of Hans Maric and Alan Gerber!
