Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015
ORCID: 0000-0003-0179-4116
Curriculum Vitae
Department of Chemistry and
Pharmaceutical Sciences
Amsterdam Institute for
Molecules, Medicines and Systems
VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands
Disclaimer/Impressum
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For more news see Twitter @TomNGrossmannBy grossmannlab on Feb 16, 2021https://twitter.com/TomNGrossmann
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University spin-off incircular BV has been formedBy grossmannlab on Feb 15, 2021We are happy to announce the incorporation of incircular BV, a university spin-off utilizing our INCYPRO protein stabilization technology. Big thanks to all involved researchers and for support by the European Research Council, the Innovation Exchange Amsterdam, the Demonstrator Lab and the Dutch Research Council.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem. 2020 and Pelay-Gimeno et al., Angew. Chem., 2018
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Book chapter on stapled peptides is now availableBy grossmannlab on Dec 10, 2020Our book chapter “Stapled Peptide Inhibitors of Protein–Protein Interactions” in “Inhibitors of Protein–Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.
Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!
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Article in Nature Communications is onlineBy grossmannlab on Oct 27, 2020“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”
H Adihou et al. Nature Commun., 11, 5425 (2020)
Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel
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Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste VazquezBy grossmannlab on Oct 10, 2020It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!
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Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grantBy grossmannlab on Jul 4, 2020Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem. 2020 and Pelay-Gimeno et al., Angew. Chem., 2018
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Welcome to Ivana DrienovskaBy grossmannlab on Jul 1, 2020
Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska
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Welcome to our MSc students Mohamed Ibrahim and Glenn PaardekooperBy grossmannlab on Jul 1, 2020Great to have Mohamed and Glenn joining our INCYPRO team!
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CORDIS features our INCYPRO technologyBy grossmannlab on Jun 28, 2020The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology: https://t.co/j5ZGsnU6Mm?amp=1
We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!
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Congratulations to Dr. Kerstin Wallraven!By grossmannlab on Jun 8, 2020Kerstin successfully defended her PhD.
Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).
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First ChemBioChem Virtual SymposiumBy grossmannlab on Jun 3, 2020The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).
The talks are now available online on youtube: https://www.youtube.com/watch?v=duc-od5S93w
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Author profile in Angewandte Chemie is onlineBy grossmannlab on Apr 28, 2020The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202005712
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Perspective in Nature Chemistry is onlineBy grossmannlab on Feb 7, 2020“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)
WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9
Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!
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Article featured as JOC supplementary CoverBy grossmannlab on Feb 7, 2020Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.
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Welcome to VENI fellow Nick PearceBy grossmannlab on Feb 5, 2020Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.
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Article in Chemical Science is onlineBy grossmannlab on Jan 22, 2020“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”
K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K
Thanks to our collaborators at AstraZeneca!
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Enjoy the holidays and all the best for the New Year!!By grossmannlab on Dec 18, 2019 |
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Durable enzymes for a green economyBy grossmannlab on Dec 12, 2019Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.
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Article in the Journal of Organic Chemistry is onlineBy grossmannlab on Dec 3, 2019“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490
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Communication in ChemBioChem is onlineBy grossmannlab on Nov 4, 2019“Lipidated stapled peptides targeting the acyl binding protein UNC119”
PM Cromm, H. Adihou, S. Kapoor, M Vazquez-Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615
Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!
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