Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
ResearcherID: A-4175-2015
ORCID: 0000-0003-0179-4116

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands


For more news see Twitter @TomNGrossmann

By grossmannlab on Dec 11, 2020

Book chapter on stapled peptides is now available

By grossmannlab on Dec 10, 2020

Our book chapter “Stapled Peptide Inhibitors of Protein–Protein Interactions” in “Inhibitors of Protein–Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.

Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!

Article in Nature Communications is online

By grossmannlab on Oct 27, 2020

“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”

H Adihou et al. Nature Commun., 11, 5425 (2020)

Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel

Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vazquez

By grossmannlab on Oct 10, 2020

It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!

Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant

By grossmannlab on Jul 4, 2020

Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.

Read more about INCYPRO here:  Neubacher et al., J. Org. Chem. 2020 and Pelay-Gimeno et al., Angew. Chem., 2018

Welcome to Ivana Drienovska

By grossmannlab on Jul 1, 2020

Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska

Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper

By grossmannlab on Jul 1, 2020

Great to have Mohamed and Glenn joining our INCYPRO team!

CORDIS features our INCYPRO technology

By grossmannlab on Jun 28, 2020

The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology:

We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!

Congratulations to Dr. Kerstin Wallraven!

By grossmannlab on Jun 8, 2020

Kerstin successfully defended her PhD.

Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).

First ChemBioChem Virtual Symposium

By grossmannlab on Jun 3, 2020

The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).

The talks are now available online on youtube:

Author profile in Angewandte Chemie is online

By grossmannlab on Apr 28, 2020

The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:



Perspective in Nature Chemistry is online

By grossmannlab on Feb 7, 2020

“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)

WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9

Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!

Article featured as JOC supplementary Cover

By grossmannlab on Feb 7, 2020

Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.

Welcome to VENI fellow Nick Pearce

By grossmannlab on Feb 5, 2020

Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.

Article in Chemical Science is online

By grossmannlab on Jan 22, 2020

“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”

K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K

Thanks to our collaborators at AstraZeneca!

Enjoy the holidays and all the best for the New Year!!

By grossmannlab on Dec 18, 2019

Durable enzymes for a green economy

By grossmannlab on Dec 12, 2019

Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.

Article in the Journal of Organic Chemistry is online

By grossmannlab on Dec 3, 2019

“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490

Communication in ChemBioChem is online

By grossmannlab on Nov 4, 2019

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H. Adihou, S. Kapoor, M Vazquez-Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

Article in Angewandte Chemie is online

By grossmannlab on Sep 23, 2019

“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D. Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!