Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute for Molecules, Medicines and Systems
Article featured as Angewandte Chemie back cover
June 11, 2021
Our article “Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling” DOI: 10.1002/anie.202102082 has been featured as back cover at Angewandte Chemie. Thanks to first author Mathias for the great cover design!
Review in ChemBioChem is online
June 1, 2021
“Protein Macrocyclization for Tertiary Structure Stabilization”
A Haim, S Neubacher, TN Grossmann DOI: 10.1002/cbic.202100111 – open access (PDF)
Article in Chem. Eur. J. is online
May 20, 2021
“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”
NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)
Article in Angewandte Chemie is online
March 30, 2021
“Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling”
M Wendt et al. DOI: 10.1002/anie.202102082 – open access (PDF)
This has been a great team effort – thanks to everyone involved!
Article in Nature Communications is online
October 27, 2020
“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”
H Adihou et al. Nature Commun., 11, 5425 (2020)
Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel
Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez
October 10, 2020
It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!
Welcome to Ivana Drienovská
July 1, 2020
Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska
Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper
July 1, 2020
Great to have Mohamed and Glenn joining our INCYPRO team!
CORDIS features our INCYPRO technology
June 28, 2020
The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology: https://t.co/j5ZGsnU6Mm?amp=1
We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!
Perspective in Nature Chemistry is online
February 7, 2020
“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)
WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9
Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!
Article featured as JOC supplementary Cover
February 7, 2020
Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.
Welcome to VENI fellow Nick Pearce
February 5, 2020
Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.
Article in Chemical Science is online
January 22, 2020
“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”
K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K
Thanks to our collaborators at AstraZeneca!
Enjoy the holidays and all the best for the New Year!!December 18, 2019