Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
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@TomNGrossmann
Big congrats to Juan for being awarded a Marie Skłodowska-Curie postdoc fellowship by the European Union! It is great to have Juan pursue his work on the design of proteomimetic scaffolds with enhanced biological function, such as inhibitors for the oncogene β-catenin.
Health~Holland supports our initiative of modulating Galectins using INCYPRO (LSHM24021) via a Public-Private Partnership Allowance. We’re looking forward to work together with Dr. Victor Thijssen (Amsterdam UMC) and the Incircular team.
Powered by Health~Holland, Top Sector Life Sciences & Health.
We wish everyone a Happy New Year!! Also, all the best to Alejandro Yeste-Vázquez who’s leaving our group to join the lab of Juan Del Valle at the University of Notre Dame.
Congratulations to Felix Paulussen for securing funding by Biotech Booster a Nationaal Groeifonds for developing cancer treatments based on the group’s findings: Yeste-Vázquez et al. Angew Chem 2024 and Wendt et al. Angew Chem 2021.
Big thanks to our technology transfer office IXA for their support!
Structure-based design of bicyclic helical peptides that target the oncogene β-catenin
A Yeste-Vázquez, FM Paulussen, M Wendt, R Klintrot, C Schulte, K Wallraven, L van Gijzel, B Simeonov, M van der Gaag, A Gerber, HM Maric, S Hennig, TN Grossmann, Angew. Chem. Int. Ed. DOI: 10.1002/anie.202411749
Thanks to the collaborating groups of Hans Maric and Alan Gerber!
Our group’s enjoying the European Peptide Symposium in Florence with great talks and posters.
Congratulations to Alejandro for receiving the 2nd prize for the Best Young Investigator Poster Presentation (Dr. Bert and Dr. Elizabetz Shram Award).
Identification of an H-Ras nanocluster disrupting peptide
CL Steffen, G Manoharan, K Pavic, A Yeste-Vázquez, M Knuuttila, N Arora, Y Zhou, H Härmä, A Gaigneaux, TN Grossmann, DK Abankwa* Commun. Biol. DOI: 10.1038/s42003-024-06523-9
Congrats to the Abankwa group and great to be able to contribute to this study!
From protein structures to functional biomimetics
C Durukan, TN Grossmann Synlett DOI: 10.1055/a-2308-1795
Binding dynamics of a stapled peptide targeting the transcription factor NF-Y
C Durukan, F Arbore, R Klintrot, C Bigiotti, IM Ilie, J Vreede, TN Grossmann*, S Hennig* ChemBioChem DOI: 10.1002/cbic.202400020
Great team effort and congratulations to everyone! Thanks to the MD contribution from our University of Amsterdam colleagues!
Felix successfully defended his thesis today!
Big thanks to co-promotor Dr. Joen Juirink!
Read more about Felix’ work here: J. Am. Chem. Soc. 2022, 144, 15303–15313
A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Yun joins our group with support from the Chinese Scholarship Council. Congratulations!
Environment-responsive peptide dimers bind and stabilize double-stranded RNA
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Bicyclic engineered Sortase A performs transpeptidation under denaturing conditions
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
