archive

Durable enzymes for a green economy

December 12, 2019

Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.

Article in the Journal of Organic Chemistry is online

December 3, 2019

“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490

Communication in ChemBioChem is online

November 4, 2019

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H Adihou, S Kapoor, M Vazquez Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

Article in Angewandte Chemie is online

September 23, 2019

“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!

Physics2Market grant

August 28, 2019

We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!

Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019

Welcome to Alessia Amore and Alan Gerber

August 5, 2019

We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!

Congratulations to Carolin Müller!

June 25, 2019

Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.

Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079–17083 (2018) – open access (PDF)

Article in BIOspektrum is online

May 12, 2019

BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.

The article can be found here (German, open access: PDF). Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018

Nina‑Louisa Efrém supported by the German Academic Scholarship Foundation

March 28, 2019

Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!

In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017

Incircular website is online!

March 8, 2019

Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.

If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay‑Gimeno et al., Angew. Chem., 2018 (open access: PDF).

Welcome to our new master students

March 6, 2019

We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!

Jordy Saya joins our team

March 1, 2019

Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.

ERC proof of concept grant

December 21, 2018

Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam

Article featured as Angewandte inside cover

December 19, 2018

Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.

Merry Christmas to everyone!

December 14, 2018

Congratulations to Arne Küpper!

December 9, 2018

Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!

Article in Angewandte Chemie is online

November 9, 2018

“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”

C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515

Simion Becker and Jaap Achten join the INCYPRO team

October 1, 2018

Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!

Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018

Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available

September 21, 2018

Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt signaling.

Read more here: Dietrich et al., Cell Chem. Biol., 2017