Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
Article in Angewandte Chemie is online
August 29, 2024
Structure-based design of bicyclic helical peptides that target the oncogene β-catenin
A Yeste-Vázquez, FM Paulussen, M Wendt, R Klintrot, C Schulte, K Wallraven, L van Gijzel, B Simeonov, M van der Gaag, A Gerber, HM Maric, S Hennig, TN Grossmann, Angew. Chem. Int. Ed. DOI: 10.1002/anie.202411749
Thanks to the collaborating groups of Hans Maric and Alan Gerber!
European Peptide Symposium 2024
August 29, 2024
Our group’s enjoying the European Peptide Symposium in Florence with great talks and posters.
Congratulations to Alejandro for receiving the 2nd prize for the Best Young Investigator Poster Presentation (Dr. Bert and Dr. Elizabetz Shram Award).
Article in Communications Biology is online
July 10, 2024
Identification of an H-Ras nanocluster disrupting peptide
CL Steffen, G Manoharan, K Pavic, A Yeste-Vázquez, M Knuuttila, N Arora, Y Zhou, H Härmä, A Gaigneaux, TN Grossmann, DK Abankwa* Commun. Biol. DOI: 10.1038/s42003-024-06523-9
Congrats to the Abankwa group and great to be able to contribute to this study!
Account in Synlett is online
April 17, 2024
From protein structures to functional biomimetics
C Durukan, TN Grossmann Synlett DOI: 10.1055/a-2308-1795
Article in ChemBioChem is online
March 19, 2024
Binding dynamics of a stapled peptide targeting the transcription factor NF-Y
C Durukan, F Arbore, R Klintrot, C Bigiotti, IM Ilie, J Vreede, TN Grossmann*, S Hennig* ChemBioChem DOI: 10.1002/cbic.202400020
Great team effort and congratulations to everyone! Thanks to the MD contribution from our University of Amsterdam colleagues!
Merry Christmas and enjoy the holidays!
December 20, 2023Article in Nature Synthesis is online
December 5, 2023
A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Article in Chem (Cell press) is online
November 2, 2023
Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Welcome to Juan Lizandra Pérez!
November 1, 2023
Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Happy Halloween 🎃 👻!
October 31, 2023Welcome to Yun Li!
October 2, 2023
Yun joins our group with support from the Chinese Scholarship Council. Congratulations!
Communication in Angewandte Chemie is online
August 22, 2023
Environment-responsive peptide dimers bind and stabilize double-stranded RNA
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
AIMMS Festival 2023
July 4, 2023
We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Welcome to Jannik, our new postdoc!
June 14, 2023
Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Article in Bioconjugate Chemistry is online
May 29, 2023
Bicyclic engineered Sortase A performs transpeptidation under denaturing conditions
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
Article in Chemical Communications is online
April 19, 2023
Non-enzymatic protein templates amide bond formation and provides catalytic turnover
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c
ERC proof-of-concept project grabRNA
April 3, 2023
The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:
A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103