Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences

Twitter-Link: @TomNGrossmann

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Article in Bioconjugate Chemistry is online

May 29, 2023

“Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions”

S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151

Great collaboration with the incircular team!

Article in Chemical Communications is online

April 19, 2023

Non-enzymatic protein templates amide bond formation and provides catalytic turnover”

N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c

Merry Christmas and enjoy the holidays!

December 18, 2022

Review in Journal of Peptide Science is online

October 24, 2022

“Peptide-based covalent inhibitors of protein-protein interactions”

FM Paulussen, TN Grossmann, J. Pept. Sci., DOI: 10.1002/psc.3457

Article in JACS is online

August 12, 2022

Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex”

FM Paulussen et al. J. Am. Chem. Soc., DOI: 10.1021/jacs.2c06304

Congratulations to the entire team at the Vrije Universiteit Amsterdam and Universiteit van Amsterdam! Great collaboration with the groups of Joen Luirink, Tanneke den Blaauwen, Peter van Ulsen, and Daan Geerke.

Review in Bioorg. Med. Chem. is online

July 14, 2022

“Targeting the interaction of ß-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling”

EMR Koelman, A Yeste-Vázquez, TN Grossmann, DOI: 10.1016/j.bmc.2022.116920 – open access (PDF)

Nick Pearce becomes assistant professor

June 23, 2022

We’re very proud to see Nick moving on to Linköping University in Sweden. Congratulations Nick!!!

Read more here: 

Nick’s homepage:

Journal of Peptide Science Editorial Advisory Board member

April 1, 2022

Tom is now member of the Editorial Advisory Board of the Journal of Peptide Science, the official journal of the European Peptide Society.

Congratulations to Dr. Niall McLoughlin!

March 28, 2022

Niall successfully defended his thesis today!

Read more about his work here: McLoughlin et al., Chem. Eur. J. 2021

Article in Antibiotics is online

February 23, 2022

“Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo”

GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273

Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!

Welcome to our new group members!

February 1, 2022

Great to have Master students Anissa Haim, Jules Bouffard, Tim Lugtenburg, Willem von Meijenfeldt, Léo Romão Soares and Olivier van Zadelhoff, as well as research associate Rasmus Klintrot joining our group.

EIC transition grant for incircular

January 28, 2022

The spin-off company incircular BV has been selected for the EIC Transition grant for utilizing our INCYPRO protein stabilization technology. Congratulations to Saskia and the entire incircular team!

Read more about INCYPRO here: Neubacher et al., J. Org. Chem. 2020 and Pelay‑Gimeno et al., Angew. Chem. 2018

Article in Nucleic Acids Research is online

December 6, 2021

“Constrained peptides mimic a viral suppressor of RNA silencing”

A Kuepper et al. Nucleic Acids Res.DOI: 10.1093/nar/gkab1149 

Congratulations to the entire team at the VU Amsterdam, University Hospital Essen, Radboud University, and the International Institute of Molecular and Cell Biology in Warsaw!

Congratulations to Dr. Sebastian Kiehstaller and Dr. Mathias Wendt!

November 30, 2021

Sebastian and Mathias successfully defended their PhDs!

Read more about their work here: Kiehstaller et al., J. Biol. Chem. 2020  and Wendt et al., Angew. Chem. 2021

New ChemBioChem Editorial Advisory Board member

October 11, 2021

Tom is now member of the Editorial Advisory Board of ChemBioChem joining a great team of Chemical Biology colleagues:

Article featured as Angewandte Chemie back cover

June 11, 2021

Our article “Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling” DOI: 10.1002/anie.202102082 has been featured as back cover at Angewandte Chemie. Thanks to first author Mathias for the great cover design!


Review in ChemBioChem is online

June 1, 2021

“Protein Macrocyclization for Tertiary Structure Stabilization”

A Haim, S Neubacher, TN Grossmann DOI: 10.1002/cbic.202100111 – open access (PDF)

Article in Chem. Eur. J. is online

May 20, 2021

“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”

NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)

Article in Angewandte Chemie is online

March 30, 2021

“Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling”

M Wendt et al. DOI: 10.1002/anie.202102082 – open access (PDF)

This has been a great team effort – thanks to everyone involved!

University spin-off incircular has been formed

February 15, 2021

We are happy to announce the incorporation of incircular BV, a university spin-off utilizing our INCYPRO protein stabilization technology. Big thanks to all involved researchers and for support by the European Research Council, the Innovation Exchange Amsterdam, the Demonstrator Lab and the Dutch Research Council.

Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018