Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
Article in Nature Synthesis is online
December 5, 2023
A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Article in Chem (Cell press) is online
November 2, 2023
Covalent Bicyclization of Protein Complexes Yields Durable Quaternary Structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Welcome to Juan Lizandra Pérez!
November 1, 2023
Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Happy Halloween 🎃 👻!October 31, 2023
Communication in Angewandte Chemie is online
August 22, 2023
Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA
NM McLoughlin, MA Albers, E Collado Camps, J Paulus, YA Ran, S Neubacher, S Hennig, R Brock, TN Grossmann Angew. Chem. Int. Ed. e202308028.
Great collaboration with the Brock lab at Radboud University!
AIMMS Festival 2023
July 4, 2023
We enjoyed the AIMMS Festival in Egmond aan Zee. Great contributions by our team! Congratulations to Felix for receiving a poster prize!
Read more about Felix’ project here: FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Welcome to Jannik, our new postdoc!
June 14, 2023
Jannik joins us from Norbert Sewald’s group and we’re happy about the additional peptide synthesis expertise!
Article in Bioconjugate Chemistry is online
May 29, 2023
Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions
S Kiehstaller, GH Hutchins, A Amore, A Gerber, M Ibrahim, S Hennig, S Neubacher, TN Grossmann, Bioconj. Chem. DOI: 10.1021/acs.bioconjchem.3c00151
Article in Chemical Communications is online
April 19, 2023
Non-enzymatic protein templates amide bond formation and provides catalytic turnover
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c
ERC proof-of-concept project grabRNA
April 3, 2023
The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:
A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103
Welcome to our new PhD candidates!
February 1, 2023
Welcome Eni Rile, Marvin Albers and Anissa Haim! Great to have you onboard!
Merry Christmas and enjoy the holidays!December 18, 2022
Review in Journal of Peptide Science is online
October 24, 2022
Peptide-based covalent inhibitors of protein-protein interactions
FM Paulussen, TN Grossmann, J. Pept. Sci. DOI: 10.1002/psc.3457
Article in JACS is online
August 12, 2022
Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex
FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Congratulations to the entire team at the Vrije Universiteit Amsterdam and Universiteit van Amsterdam! Great collaboration with the groups of Joen Luirink, Tanneke den Blaauwen, Peter van Ulsen, and Daan Geerke.
Review in Bioorg. Med. Chem. is online
July 14, 2022
Targeting the interaction of ß-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling
EMR Koelman, A Yeste-Vázquez, TN Grossmann, DOI: 10.1016/j.bmc.2022.116920 – open access (PDF)
Article in Antibiotics is online
February 23, 2022
Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo
GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273
Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!