Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences

Twitter-Link: @TomNGrossmann

For more news, visit us at Twitter:

New ChemBioChem Editorial Advisory Board member

October 11, 2021

Tom is now member of the Editorial Advisory Board of ChemBioChem joining a great team of Chemical Biology colleagues:

Article featured as Angewandte Chemie back cover

June 11, 2021

Our article “Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling” DOI: 10.1002/anie.202102082 has been featured as back cover at Angewandte Chemie. Thanks to first author Mathias for the great cover design!


Review in ChemBioChem is online

June 1, 2021

“Protein Macrocyclization for Tertiary Structure Stabilization”

A Haim, S Neubacher, TN Grossmann DOI: 10.1002/cbic.202100111 – open access (PDF)

Article in Chem. Eur. J. is online

May 20, 2021

“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”

NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)

Article in Angewandte Chemie is online

March 30, 2021

“Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling”

M Wendt et al. DOI: 10.1002/anie.202102082 – open access (PDF)

This has been a great team effort – thanks to everyone involved!

University spin-off incircular has been formed

February 15, 2021

We are happy to announce the incorporation of incircular BV, a university spin-off utilizing our INCYPRO protein stabilization technology. Big thanks to all involved researchers and for support by the European Research Council, the Innovation Exchange Amsterdam, the Demonstrator Lab and the Dutch Research Council.

Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018

Book chapter on stapled peptides is now available

December 10, 2020

Our book chapter “Stapled Peptide Inhibitors of Protein-Protein Interactions” in “Inhibitors of Protein-Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.

Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!

Article in Nature Communications is online

October 27, 2020

“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”

H Adihou et al. Nature Commun., 11, 5425 (2020)

Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel

Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez

October 10, 2020

It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!

Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant

July 4, 2020

Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.

Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018

Welcome to Ivana Drienovská

July 1, 2020

Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska

Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper

July 1, 2020

Great to have Mohamed and Glenn joining our INCYPRO team!

CORDIS features our INCYPRO technology

June 28, 2020

The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology:

We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!

Congratulations to Dr. Kerstin Wallraven!

June 8, 2020

Kerstin successfully defended her PhD.

Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).

First ChemBioChem Virtual Symposium

June 3, 2020

The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).

The talks are now available online on youtube:

Author profile in Angewandte Chemie is online

April 28, 2020

The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:

Perspective in Nature Chemistry is online

February 7, 2020

“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)

WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9

Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!

Article featured as JOC supplementary Cover

February 7, 2020

Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.

Welcome to VENI fellow Nick Pearce

February 5, 2020

Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.

Article in Chemical Science is online

January 22, 2020

“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”

K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K

Thanks to our collaborators at AstraZeneca!