X-Ray Crystallography

Our workflow includes liquid handling for sample crystallization at two temperatures (4 °C and 20 °C), crystal optimization as well as handling including cryo-protection and storage. Diffraction analysis and data collection is performed at a synchrotron or on our in-house, state of the art Bruker D8 Quest X-Ray source attached to an cutting edge Photon 2 detector including downstream software suits for structure determination.

Wnt and Hippo signalling

6SBA
PDB ID: 6SBA
TEAD + macrocyclic 20-mer
Nature Commun. 2020


PDB ID: 7AR4
beta-catenin + cyclic beta-hairpin
Angew. Chem. Int. Ed. 2021

 

INCYPRO-stabilized enzyme


PDB ID: 8PI1
bicyclic PFE trimer
Chem. 2024

 

 

Nuclear Transription Factor Y

6QMS
PDB ID: 6QMS
NF-YB/C + stapled peptide
Angew. Chem. Int. Ed. 2019

6QMP
PDB ID: 6QMP
NF-YB/C + NF-YA peptide
Angew. Chem. Int. Ed. 2019

6QMQ
PDB ID: 6QMQ
NF-YB/C + stapled peptide
Angew. Chem. Int. Ed. 2019

Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)

5BZZ
PDB ID: 5BZZ
PTEN
Angew. Chem. Int. Ed. 2015

5BZX
PDB ID: 5BZX
PTEN oxidized by bpV-phen
Angew. Chem. Int. Ed. 2015

5BUG
PDB ID: 5BUG
PTEN oxidized by H2O2
Angew. Chem. Int. Ed. 2015

Human Adaptor Protein 14-3-3

6RLZ
PDB ID: 6RLZ
14-3-3 + macrocylic 8-mer
Chem. Sci. 2020

5JM4
PDB ID: 5JM4
14-3-3 + adamantyl peptide
J. Med. Chem. 2017

5J31
PDB ID: 5J31
14-3-3 + alkyne cyclized peptide
ChemBioChem 2016

4N7Y
PDB ID: 4N7Y
14-3-3 + 8C-linked peptide
Angew. Chem. Int. Ed. 2014

4N84
PDB ID: 4N84
14-3-3 + 12C-linked peptide
Angew. Chem. Int. Ed. 2014

4N7G
PDB ID: 4N7G
14-3-3 + ExoS peptide
Angew. Chem. Int. Ed. 2014