Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015
ORCID: 0000-0003-0179-4116

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands

Disclaimer/Impressum

X-Ray Crystallography

Our workflow includes liquid handling for sample crystallization at two temperatures (4 °C and 20 °C), crystal optimization as well as handling including cryo-protection and storage. Diffraction analysis and data collection is performed at a synchrotron or on our in-house, state of the art Bruker D8 Quest X-ray source attached to an cutting edge Photon 2 detector including downstream software suits for structure determination.

 

Nuclear Transcription Factor Y (NF-Y)


PDB ID: 6QMP
NF-YB/C + NF-YA peptide
Angew. Chem. Int. Ed. 2019 


PDB ID: 6QMQ
NF-YB/C + stapled peptide
Angew. Chem. Int. Ed. 2019 


PDB ID: 6QMS
NF-YB/C + stapled peptide
Angew. Chem. Int. Ed. 2019 

 

Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)


PDB ID: 5BZZ
PTEN
Angew. Chem. Int. Ed. 2015 


PDB ID: 5BZX
PTEN oxidized by bpV-phen
Angew. Chem. Int. Ed. 2015 


PDB ID: 5BUG
PTEN oxidized by H2O2
Angew. Chem. Int. Ed. 2015 

 

Human Adaptor Protein 14-3-3


PDB ID: 5JM4
14-3-3 + adamantyl peptide
J. Med. Chem. 2017


PDB ID: 5J31
14-3-3 + alkyne cyclized peptide
ChemBioChem 2016


PDB ID: 4N7G
14-3-3 + ExoS peptide
Angew. Chem. Int. Ed. 2014


PDB ID: 4N7Y
14-3-3 + 8C-linked peptide
Angew. Chem. Int. Ed. 2014


PDB ID: 4N84
14-3-3 + 12C-linked peptide
Angew. Chem. Int. Ed. 2014