Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute for Molecules, Medicines and Systems
Article in Angewandte Chemie is online
September 23, 2019
“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”
S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790
Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!
Welcome to Alessia Amore and Alan Gerber
August 5, 2019
We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!
Congratulations to Carolin Müller!
June 25, 2019
Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.
Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079–17083 (2018) – open access (PDF)
Article in BIOspektrum is online
May 12, 2019
BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.
The article can be found here (German, open access: PDF). Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Nina‑Louisa Efrém supported by the German Academic Scholarship Foundation
March 28, 2019
Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!
In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017
Welcome to our new master students
March 6, 2019
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy Saya joins our team
March 1, 2019
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Article featured as Angewandte inside cover
December 19, 2018
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
Merry Christmas to everyone!December 14, 2018
Congratulations to Arne Küpper!
December 9, 2018
Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
Article in Angewandte Chemie is online
November 9, 2018
“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
Simion Becker and Jaap Achten join the INCYPRO team
October 1, 2018
Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available
September 21, 2018
Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
Article in Applied Microbiology and Biotechnology is online
August 27, 2018
Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
Article in the journal RNA is online
August 10, 2018
“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
Article in mBio accepted and available via bioRxiv
August 8, 2018
Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite‑Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335