Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences

Twitter-Link: @TomNGrossmann

For more news, visit us at Twitter:

Book chapter on stapled peptides is now available

December 10, 2020

Our book chapter “Stapled Peptide Inhibitors of Protein-Protein Interactions” in “Inhibitors of Protein-Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.

Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!

Article in Nature Communications is online

October 27, 2020

“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”

H Adihou et al. Nature Commun., 11, 5425 (2020)

Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel

Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez

October 10, 2020

It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!

Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant

July 4, 2020

Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.

Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018

Welcome to Ivana Drienovská

July 1, 2020

Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska

Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper

July 1, 2020

Great to have Mohamed and Glenn joining our INCYPRO team!

CORDIS features our INCYPRO technology

June 28, 2020

The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology:

We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!

Congratulations to Dr. Kerstin Wallraven!

June 8, 2020

Kerstin successfully defended her PhD.

Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).

First ChemBioChem Virtual Symposium

June 3, 2020

The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).

The talks are now available online on youtube:

Author profile in Angewandte Chemie is online

April 28, 2020

The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:

Perspective in Nature Chemistry is online

February 7, 2020

“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)

WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9

Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!

Article featured as JOC supplementary Cover

February 7, 2020

Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.

Welcome to VENI fellow Nick Pearce

February 5, 2020

Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.

Article in Chemical Science is online

January 22, 2020

“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”

K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K

Thanks to our collaborators at AstraZeneca!

Enjoy the holidays and all the best for the New Year!!

December 18, 2019

Durable enzymes for a green economy

December 12, 2019

Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.

Article in the Journal of Organic Chemistry is online

December 3, 2019

“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490

Communication in ChemBioChem is online

November 4, 2019

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H Adihou, S Kapoor, M Vazquez Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

Article in Angewandte Chemie is online

September 23, 2019

“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!

Physics2Market grant

August 28, 2019

We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!

Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019