Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute for Molecules, Medicines and Systems
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Article in the Journal of Organic Chemistry is onlineDecember 3, 2019
“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490
Communication in ChemBioChem is onlineNovember 4, 2019
“Lipidated stapled peptides targeting the acyl binding protein UNC119”
PM Cromm, H Adihou, S Kapoor, M Vazquez Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615
Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!
Article in Angewandte Chemie is onlineSeptember 23, 2019
“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”
S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790
Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!
Physics2Market grantAugust 28, 2019
Welcome to Alessia Amore and Alan GerberAugust 5, 2019
We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!
Nina‑Louisa Efrém supported by the German Academic Scholarship FoundationMarch 28, 2019
Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!
In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017
Incircular website is online!March 8, 2019
Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.
Welcome to our new master studentsMarch 6, 2019
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy Saya joins our teamMarch 1, 2019
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Article featured as Angewandte inside coverDecember 19, 2018
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
Merry Christmas to everyone!December 14, 2018
Congratulations to Arne Küpper!December 9, 2018
Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
Article in Angewandte Chemie is onlineNovember 9, 2018
“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
Simion Becker and Jaap Achten join the INCYPRO teamOctober 1, 2018
Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018