Article in Chem. Eur. J. is online
May 20, 2021“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”
NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)
Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Bluesky:
@TomNGrossmann
Article in Angewandte Chemie is online
March 30, 2021“Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling”
M Wendt et al. DOI: 10.1002/anie.202102082 – open access (PDF)
This has been a great team effort – thanks to everyone involved!
University spin-off incircular has been formed
February 15, 2021We are happy to announce the incorporation of incircular BV, a university spin-off utilizing our INCYPRO protein stabilization technology. Big thanks to all involved researchers and for support by the European Research Council, the Innovation Exchange Amsterdam, the Demonstrator Lab and the Dutch Research Council.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018
Book chapter on stapled peptides is now available
December 10, 2020Our book chapter “Stapled Peptide Inhibitors of Protein-Protein Interactions” in “Inhibitors of Protein-Protein Interactions: Small Molecules, Peptides and Macrocycles” by the Royal Society of Chemistry and edited by Ali Tavassoli has been published.
Congrats to Mathias and Niall, and thanks to Ali for putting together this great collection!
Article in Nature Communications is online
October 27, 2020“A protein tertiary structure mimetic modulator of the Hippo signalling pathway”
H Adihou et al. Nature Commun., 11, 5425 (2020)
Thanks to our collaboration partners at the Max Planck Insitute for Molecular Physiology, AstraZeneca, the A*STAR Institute in Singapure and Christian-Albrechts-University of Kiel
Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez
October 10, 2020It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!
Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant
July 4, 2020Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018
Welcome to Ivana Drienovská
July 1, 2020Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska
Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper
July 1, 2020Great to have Mohamed and Glenn joining our INCYPRO team!
CORDIS features our INCYPRO technology
June 28, 2020The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology: https://t.co/j5ZGsnU6Mm?amp=1
We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!
Congratulations to Dr. Kerstin Wallraven!
June 8, 2020Kerstin successfully defended her PhD.
Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).
First ChemBioChem Virtual Symposium
June 3, 2020The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).
The talks are now available online on youtube: https://www.youtube.com/watch?v=duc-od5S93w
Author profile in Angewandte Chemie is online
April 28, 2020The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202005712
Perspective in Nature Chemistry is online
February 7, 2020“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)
WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9
Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!
Article featured as JOC supplementary Cover
February 7, 2020Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.
Welcome to VENI fellow Nick Pearce
February 5, 2020Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.
Article in Chemical Science is online
January 22, 2020“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”
K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K
Thanks to our collaborators at AstraZeneca!
Enjoy the holidays and all the best for the New Year!!
December 18, 2019
Article in the Journal of Organic Chemistry is online
December 3, 2019“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490