Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute for Molecules, Medicines and Systems

Twitter-Link: @TomNGrossmann

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Article in Angewandte Chemie is online

May 30, 2018

“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”

M Pelay‑Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)

Article in Osteoarthritis and Cartilage is online

March 21, 2018

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908

Felix Paulußen joins our team

January 15, 2018

Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!

All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!

Merry Christmas!

December 18, 2017

All the best for the holidays and the New Year!

Perspective in Cell Chemical Biology is online

November 17, 2017

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009

Article in Chemistry – A European Journal is online

October 20, 2017

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Article in the Journal of Medicinal Chemistry is online

October 14, 2017

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch*, S Hennig*, TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221

Communication in Chemistry – A European Journal is online

August 5, 2017

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle-receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776

Article in Cell Chemical Biology is online

July 27, 2017

“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-catenin Protein-Protein Interactions”

L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013

We thank our collaborators for their contributions!!

Congratulations to Laura Dietrich

July 25, 2017

Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-catenin Signalwegs”.

Our work was highlighted in the latest issue of EU Research

July 22, 2017

Combining the best of small molecules and biologics (page 12)

Article in Nature Communications is online

March 23, 2017

Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!

“Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”

MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks‑Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690

Poster prizes for Kerstin Wallraven and Adrian Glas

March 22, 2017

Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!

Review in Angewandte Chemie is online

February 10, 2017

Congratulations to the entire AztraZeneca/MPI satellite team!

“New modalities for challanging targets in drug discovery”

E Valeur*, SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914

Niall McLoughlin and Mathias Wendt (re)join our team

January 2, 2017

Welcome, Niall and Mathias! All the best for your PhD research!

Article in ACS Chemical Biology is online

December 21, 2016

“Translocation of an intracellular protein via peptide-directed ligation”

C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013

Merry Christmas!

December 20, 2016

We wish you a merry Christmas and a happy New Year!

Congratulations to Christiane Stiller

December 8, 2016

Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.

Congratulations to Adrian Glas

September 22, 2016

Adrian successfully defended his PhD thesis “Kohlenwasserstoff-verbrückte Peptide mit irregulärer Sekundärstruktur für die Inhibition von Protein-Protein-Interaktionen”.

Communication in ChemBioChem is online

September 6, 2016

“Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis”

PM Cromm, K Wallraven, A Glas, D Bier, A Fürstner, C Ottmann, TN Grossmann*, DOI: 10.1002/cbic.201600362