Welcome to Stefanie Hanreich, Canan Durukan and Alejandro Yeste Vázquez
October 10, 2020It is great to have Steffie, Canan and Alejandro joining our team as new PhD students!
Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Twitter:
@TomNGrossmann
Congratulations to Saskia Neubacher for receiving an NWO Take-off 1 grant
July 4, 2020Saskia received support by the NWO (Take-off phase 1) for a feasibility study related to our INCYPRO protein stabilization technology.
Read more about INCYPRO here: Neubacher et al., J. Org. Chem., 2020 and Pelay‑Gimeno et al., Angew. Chem., 2018
Welcome to Ivana Drienovská
July 1, 2020Ivana joins our group as assistant professor working in the field of biocatalysis. If you want to know more you can follow Ivana on Twitter @IvanaDrienovska
Welcome to our MSc students Mohamed Ibrahim and Glenn Paardekooper
July 1, 2020Great to have Mohamed and Glenn joining our INCYPRO team!
CORDIS features our INCYPRO technology
June 28, 2020The Community R&D Information Service (CORDIS) of the European Commission features our INCYPRO protein stabilization technology: https://t.co/j5ZGsnU6Mm?amp=1
We are grateful for support by the European Research Council via an ERC Proof-of-Concept grant!
Congratulations to Dr. Kerstin Wallraven!
June 8, 2020Kerstin successfully defended her PhD.
Read more about Kerstin’s work here: Chem. Sci., 11, 2269–2276 (2020), Biomed. Pharmacol., 177, 113938 (2020) and ChemBioChem 17, 1915–1919 (2016).
First ChemBioChem Virtual Symposium
June 3, 2020The symposium features 20 min presentations by Tom, Alison Narayan (University of Michigan) and Gonçalo Bernardes (University of Cambridge).
The talks are now available online on youtube: https://www.youtube.com/watch?v=duc-od5S93w
Author profile in Angewandte Chemie is online
April 28, 2020The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202005712
Perspective in Nature Chemistry is online
February 7, 2020“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)
WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9
Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!
Article featured as JOC supplementary Cover
February 7, 2020Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.
Welcome to VENI fellow Nick Pearce
February 5, 2020Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.
Article in Chemical Science is online
January 22, 2020“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”
K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K
Thanks to our collaborators at AstraZeneca!
Enjoy the holidays and all the best for the New Year!!
December 18, 2019
Article in the Journal of Organic Chemistry is online
December 3, 2019“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490
Communication in ChemBioChem is online
November 4, 2019“Lipidated stapled peptides targeting the acyl binding protein UNC119”
PM Cromm, H Adihou, S Kapoor, M Vazquez Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615
Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!
Article in Angewandte Chemie is online
September 23, 2019“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”
S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790
Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!
Physics2Market grant
August 28, 2019We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019
Welcome to Alessia Amore and Alan Gerber
August 5, 2019We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!
Congratulations to Carolin Müller!
June 25, 2019Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.
Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079–17083 (2018) – open access (PDF)