Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
Nina‑Louisa Efrém supported by the German Academic Scholarship Foundation
March 28, 2019
Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!
In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017
Welcome to our new master students
March 6, 2019
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy Saya joins our team
March 1, 2019
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Article featured as Angewandte inside cover
December 19, 2018
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
Merry Christmas to everyone!December 14, 2018
Congratulations to Arne Küpper!
December 9, 2018
Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
Article in Angewandte Chemie is online
November 9, 2018
“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
Simion Becker and Jaap Achten join the INCYPRO team
October 1, 2018
Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available
September 21, 2018
Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
Article in Applied Microbiology and Biotechnology is online
August 27, 2018
Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
Article in the journal RNA is online
August 10, 2018
“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
Article in mBio accepted and available via bioRxiv
August 8, 2018
Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite‑Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335
Article in Angewandte Chemie is online
May 30, 2018
“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”
M Pelay‑Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)
Article in Osteoarthritis and Cartilage is online
March 21, 2018
Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
Felix Paulußen joins our team
January 15, 2018
Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!
All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!
December 18, 2017
All the best for the holidays and the New Year!
Perspective in Cell Chemical Biology is online
November 17, 2017
“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009