Prof. Dr. Tom N. Grossmann
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute for Molecules, Medicines and Systems
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Article in Osteoarthritis and Cartilage is onlineMarch 21, 2018
Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
Merry Christmas!December 18, 2017
All the best for the holidays and the New Year!
Perspective in Cell Chemical Biology is onlineNovember 17, 2017
“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
Article in Chemistry – A European Journal is onlineOctober 20, 2017
“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
Article in the Journal of Medicinal Chemistry is onlineOctober 14, 2017
“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch*, S Hennig*, TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221
Communication in Chemistry – A European Journal is onlineAugust 5, 2017
This communication is featured on the inside cover.
“Increased conformational flexibility of a macrocycle-receptor complex contributes to reduced dissociation rates”
A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776
Article in Cell Chemical Biology is onlineJuly 27, 2017
“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-catenin Protein-Protein Interactions”
L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013
We thank our collaborators for their contributions!!
Congratulations to Laura DietrichJuly 25, 2017
Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-catenin Signalwegs”.
Our work was highlighted in the latest issue of EU ResearchJuly 22, 2017
Article in Nature Communications is onlineMarch 23, 2017
Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!
“Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”
MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks‑Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690
Poster prizes for Kerstin Wallraven and Adrian GlasMarch 22, 2017
Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!
Review in Angewandte Chemie is onlineFebruary 10, 2017
Congratulations to the entire AztraZeneca/MPI satellite team!
“New modalities for challanging targets in drug discovery”
E Valeur*, SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914
Niall McLoughlin and Mathias Wendt (re)join our teamJanuary 2, 2017
Welcome, Niall and Mathias! All the best for your PhD research!
Article in ACS Chemical Biology is onlineDecember 21, 2016
“Translocation of an intracellular protein via peptide-directed ligation”
C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013
Merry Christmas!December 20, 2016
We wish you a merry Christmas and a happy New Year!
Congratulations to Christiane StillerDecember 8, 2016
Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.
Congratulations to Adrian GlasSeptember 22, 2016
Adrian successfully defended his PhD thesis “Kohlenwasserstoff-verbrückte Peptide mit irregulärer Sekundärstruktur für die Inhibition von Protein-Protein-Interaktionen”.
Communication in ChemBioChem is onlineSeptember 6, 2016
“Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis”
PM Cromm, K Wallraven, A Glas, D Bier, A Fürstner, C Ottmann, TN Grossmann*, DOI: 10.1002/cbic.201600362