Grossmann |
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Prof. Dr. Tom N. GrossmannChair of Biomimetic Chemistry Department of Chemistry and Amsterdam Institute for VU University Amsterdam |
PublicationsStapled Peptide Inhibitors of Protein–Protein Interactions
A protein tertiary structure mimetic modulator of the Hippo signalling pathway
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns (perspective)
Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis
Macrocyclic modalities combining peptide epitopes and natural product fragments
Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility
In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability
2019 Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
Lipidated stapled peptides targeting the acyl binding protein UNC119
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft
2018 Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
Protein-RNA interactions: Structural characteristics and hotspot amino acids
Linking Cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners
Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB
In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage
Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction
The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein (perspective)
2017 Structure-based design of non-natural macrocyclic peptides that inhibit protein-protein interactions Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein‒protein interactions Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalyzed arginylation of N-end rule targets New modalities for challanging targets in drug discovery (review) Translocation of an intracellular protein via peptide-directed ligation 2016 Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis Selective protein hyperpolarization in cell lysates using targeted dynamic nuclear polarization Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides 2015 Redox modulation of PTEN phosphatase activty by hydrogen peroxide and bisperoxidovanadium complexes Direct modulation of small GTPase activity and function (review) Structure-based design of inhibitors of protein-protein interactions: Mimicking peptide binding epitopes (review) Towards understanding cell penetration by stapled peptides Hydrocarbon stapled peptides as modulators of biological function (review) Constraining peptide conformations with the help of ring-closing metathesis (synpacts) 2014 Small-molecule modulation of Ras signaling (review) Protein-templated peptide ligation Modulators of protein-protein interactions (review) Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction Direct targeting of Rab-GTPase-effector interactions Targeting the transcriptional hub β-catenin using stapled peptides 2013 Means and methods for treating Pseudomonas infection Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling (review) Chemical Biology 2012: From drug targets to biological systems and back (conference report) 2012 Reversible covalent inhibition of a protein target (highlight)
Postdoc, Graduate and Undergraduate researchInhibition of oncogenic Wnt signaling through direct targeting of β-catenin Synthesis of all-hydrocarbon stapled α-helical peptides via ring-closing olefin metathesis DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides DNA-triggered synthesis and bioactivity of proapoptotic peptides Semi-rational design of β-catenin targeting peptides for the inhibition of Wnt-dependent signalling (conference abstract) Beta-catenin targeting peptides and uses thereof Bifunctional stapled polypeptides and uses thereof Nucleic acid-templated reactions: Consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity New aspects in fragmentation of peptide nucleic acids: Comparison of positive and negative ions by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry Chemical control of biomolecular interaction modules Photo-thermal haptotropism in cyclopentadienylcobalt complexes of linear phenylenes: Intercyclobutadiene metal migration Target-catalyzed transfer reactions for the amplified detection of RNA Single nucleotide polymorphism Achieving turnover in DNA-templated reactions (review) Inducing the replacement of PNA in DNA·PNA duplexes by DNA Triplex molecular beacons as modular probes for DNA detection Probe for detecting a particular nucleic acid sequence DNA-catalyzed transfer of a reporter group Methods for detecting target nucleic acids using template catalysed transfer reactions |
