Institute of Organic and Biomolecular Chemistry
Faculty of Chemistry
Georg-August-Universität Göttingen
For more news, visit us at Bluesky:
@TomNGrossmann
Stabilizing proteins by chemical cross-linking: Insights into conformation, unfolding, and aggregation using native ion mobility mass spectrometry
Our group attended the Polish Peptide Symposium with great talks and posters. Thanks to the organisers for the exciting event! Congratulations to Felix Paulußen for winning the Award for the Best Poster Presentation.
After nearly a decade at the Vrije Universiteit Amsterdam, Tom is starting a new position at the University of Göttingen. A big THANK YOU to everyone in the group who supported our research and teaching activities throughout the years!!
Helicity-Dependent Enzymatic Peptide Cyclisation
C Durukan, J Faierson, I van der Wal, J Lizandra Pérez, S Hennig, TN Grossmann
J. Pept. Sci. DOI: 10.1002/psc.70024
Big congrats to Juan for being awarded a Marie Skłodowska-Curie postdoc fellowship by the European Union! It is great to have Juan pursue his work on the design of proteomimetic scaffolds with enhanced biological function, such as inhibitors for the oncogene β-catenin.
Health~Holland supports our initiative of modulating Galectins using INCYPRO (LSHM24021) via a Public-Private Partnership Allowance. We’re looking forward to work together with Dr. Victor Thijssen (Amsterdam UMC) and the Incircular team.
Powered by Health~Holland, Top Sector Life Sciences & Health.
We wish everyone a Happy New Year!! Also, all the best to Alejandro Yeste-Vázquez who’s leaving our group to join the lab of Juan Del Valle at the University of Notre Dame.
Congratulations to Felix Paulussen for securing funding by Biotech Booster a Nationaal Groeifonds for developing cancer treatments based on the group’s findings: Yeste-Vázquez et al. Angew Chem 2024 and Wendt et al. Angew Chem 2021.
Big thanks to our technology transfer office IXA for their support!
Structure-based design of bicyclic helical peptides that target the oncogene β-catenin
A Yeste-Vázquez, FM Paulussen, M Wendt, R Klintrot, C Schulte, K Wallraven, L van Gijzel, B Simeonov, M van der Gaag, A Gerber, HM Maric, S Hennig, TN Grossmann, Angew. Chem. Int. Ed. DOI: 10.1002/anie.202411749
Thanks to the collaborating groups of Hans Maric and Alan Gerber!
Our group’s enjoying the European Peptide Symposium in Florence with great talks and posters.
Congratulations to Alejandro for receiving the 2nd prize for the Best Young Investigator Poster Presentation (Dr. Bert and Dr. Elizabetz Shram Award).
Identification of an H-Ras nanocluster disrupting peptide
CL Steffen, G Manoharan, K Pavic, A Yeste-Vázquez, M Knuuttila, N Arora, Y Zhou, H Härmä, A Gaigneaux, TN Grossmann, DK Abankwa* Commun. Biol. DOI: 10.1038/s42003-024-06523-9
Congrats to the Abankwa group and great to be able to contribute to this study!
From protein structures to functional biomimetics
C Durukan, TN Grossmann Synlett DOI: 10.1055/a-2308-1795
Binding dynamics of a stapled peptide targeting the transcription factor NF-Y
C Durukan, F Arbore, R Klintrot, C Bigiotti, IM Ilie, J Vreede, TN Grossmann*, S Hennig* ChemBioChem DOI: 10.1002/cbic.202400020
Great team effort and congratulations to everyone! Thanks to the MD contribution from our University of Amsterdam colleagues!
Felix successfully defended his thesis today!
Big thanks to co-promotor Dr. Joen Juirink!
Read more about Felix’ work here: J. Am. Chem. Soc. 2022, 144, 15303–15313
A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins
M Bernús, D Mazzarella, J Stanić, Z Zhai, A Yeste-Vázquez, O Boutureira, AFG Gargano, TN Grossmann, T Noël* Nature Synth. DOI 10.1038/s44160-023-00441-0
Congrats to the Noël group and great to be part of the team!
Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, et al. Chem. DOI: 10.1016/j.chempr.2023.10.003
Juan joins us from Łukasz Berlicki’s group at Wroclaw University.
We’re happy about the additional peptide design and synthesis expertise!
Yun joins our group with support from the Chinese Scholarship Council. Congratulations!
