Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Bluesky:
@TomNGrossmann
The KWF funded project ‘WINCE: Wnt inhibitors to treat colorectal cancer’ (joint with the Vermeulen lab) has started. It’s based on our Wnt inhibitors:
M Wendt et al. Angew. Chem. DOI: 10.1002/anie.202102082
L Dietrich et al. Cell Chem. Biol. DOI: 10.1016/j.chembiol.2017.06.013
Non-enzymatic protein templates amide bond formation and provides catalytic turnover
N Brauckhoff, L Fang, A Haim, TN Grossmann, ChemComm, DOI: 10.1039/d3cc00514c
The ERC funded project ‘grabRNA: Smart RNA delivery for therapy and diagnostic’ has started. It’s based on our peptidic RNA binders:
A Kuepper et al. Nucleic Acids Res. DOI: 10.1093/nar/gkab1149
NM McLoughlin et al. Chem. Eur. J. DOI: 10.1002/chem.202101103
Welcome Eni Rile, Marvin Albers and Anissa Haim! Great to have you onboard!
Peptide-based covalent inhibitors of protein-protein interactions
FM Paulussen, TN Grossmann, J. Pept. Sci. DOI: 10.1002/psc.3457
Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex
FM Paulussen et al. J. Am. Chem. Soc. DOI: 10.1021/jacs.2c06304
Congratulations to the entire team at the Vrije Universiteit Amsterdam and Universiteit van Amsterdam! Great collaboration with the groups of Joen Luirink, Tanneke den Blaauwen, Peter van Ulsen, and Daan Geerke.
Targeting the interaction of ß-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling
EMR Koelman, A Yeste-Vázquez, TN Grossmann, DOI: 10.1016/j.bmc.2022.116920 – open access (PDF)
We’re very proud to see Nick moving on to Linköping University in Sweden. Congratulations Nick!!!
Read more here: https://www.scilifelab.se/news/new-ddls-fellow-nicholas-pearce
Nick’s homepage: https://macromolecular.github.io
Tom is now member of the Editorial Advisory Board of the Journal of Peptide Science, the official journal of the European Peptide Society.
Niall successfully defended his thesis today!
Read more about his work here: McLoughlin et al., Chem. Eur. J. 2021
Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo
GK Schouten, FM Paulussen, OP Kuipers, W Bitter, TN Grossmann, P van Ulsen, Antibiotics DOI: 10.3390/antibiotics11020273
Great collaboration with the groups of Peter van Ulsen and Wilbert Bitter!
Great to have Master students Anissa Haim, Jules Bouffard, Tim Lugtenburg, Willem von Meijenfeldt, Léo Romão Soares and Olivier van Zadelhoff, as well as research associate Rasmus Klintrot joining our group.
The spin-off company incircular BV has been selected for the EIC Transition grant for utilizing our INCYPRO protein stabilization technology. Congratulations to Saskia and the entire incircular team!
Read more about INCYPRO here: Neubacher et al., J. Org. Chem. 2020 and Pelay‑Gimeno et al., Angew. Chem. 2018
“Constrained peptides mimic a viral suppressor of RNA silencing”
A Kuepper et al. Nucleic Acids Res., DOI: 10.1093/nar/gkab1149
Congratulations to the entire team at the VU Amsterdam, University Hospital Essen, Radboud University, and the International Institute of Molecular and Cell Biology in Warsaw!
Sebastian and Mathias successfully defended their PhDs!
Read more about their work here: Kiehstaller et al., J. Biol. Chem. 2020 and Wendt et al., Angew. Chem. 2021
Tom is now member of the Editorial Advisory Board of ChemBioChem joining a great team of Chemical Biology colleagues:
https://chemistry-europe.onlinelibrary.wiley.com/hub/journal/14397633/editorial-board
Our article “Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling” DOI: 10.1002/anie.202102082 has been featured as back cover at Angewandte Chemie. Thanks to first author Mathias for the great cover design!
“Protein Macrocyclization for Tertiary Structure Stabilization”
A Haim, S Neubacher, TN Grossmann DOI: 10.1002/cbic.202100111 – open access (PDF)
“Synergistic DNA- and protein-based recognition promote an RNA-templated bio-orthogonal reaction”
NM McLoughlin, A Kuepper, S Neubacher, TN Grossmann DOI: 10.1002/chem.202101103 – open access (PDF)
