Welcome to our new master students
March 6, 2019We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Twitter:
@TomNGrossmann
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.
Read more here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite‑Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335
Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.
Read more here: Krüger et al., RNA, 2018
“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”
M Pelay‑Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)
Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.
“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”
A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908
Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!
All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!
All the best for the holidays and the New Year!
“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch*, S Hennig*, TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221