Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
For more news, visit us at Bluesky:
@TomNGrossmann
“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”
S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790
Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!
We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019
We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!
Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.
Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079–17083 (2018) – open access (PDF)
BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.
The article can be found here (German, open access: PDF). Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!
In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017
Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.
If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay‑Gimeno et al., Angew. Chem., 2018 (open access: PDF).
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.
Read more here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!
“Coiled-coil peptide beacon: A tuneable conformational switch for protein detection”
C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515
Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt signaling.
Read more here: Dietrich et al., Cell Chem. Biol., 2017
Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!
“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”
S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4
“Protein-RNA interactions: Structural characteristics and hotspot amino acids”
DM Krüger, S Neubacher, TN Grossmann*, DOI: 10.1261/rna.066464.118
Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!
“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”
D Kureisaite‑Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv doi.org/10.1101/362335
Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.
Read more here: Krüger et al., RNA, 2018
