Institute of Organic and Biomolecular Chemistry
Faculty of Chemistry
Georg-August-Universität Göttingen
For more news, visit us at Bluesky:
@TomNGrossmann
“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)
WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9
Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!
Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.
Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.
“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”
K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K
Thanks to our collaborators at AstraZeneca!
“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490
“Lipidated stapled peptides targeting the acyl binding protein UNC119”
PM Cromm, H Adihou, S Kapoor, M Vazquez Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615
Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!
“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”
S Jeganathan, M Wendt, S Kiehstaller, D Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790
Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!
We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!
Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019
We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!
Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.
Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079–17083 (2018) – open access (PDF)
BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.
The article can be found here (German, open access: PDF). Read more about INCYPRO here: Pelay‑Gimeno et al., Angew. Chem., 2018
Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!
In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017
Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.
If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay‑Gimeno et al., Angew. Chem., 2018 (open access: PDF).
We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina‑Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!
Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.
Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.
Read more here: Pelay‑Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam
Our article “Coiled-coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.
