
Perspective in Cell Chemical Biology is online
November 17, 2017“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
Chair of Biomimetic Chemistry
Department of Chemistry and Pharmaceutical Sciences
Amsterdam Institute of Molecular and Life Sciences
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“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”
NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009
“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”
B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338
“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”
DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch*, S Hennig*, TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221
This communication is featured on the inside cover.
“Increased conformational flexibility of a macrocycle-receptor complex contributes to reduced dissociation rates”
A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776
“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-catenin Protein-Protein Interactions”
L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013
We thank our collaborators for their contributions!!
Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-catenin Signalwegs”.
Combining the best of small molecules and biologics (page 12)
Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!
“Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”
MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks‑Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690
Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!
Congratulations to the entire AztraZeneca/MPI satellite team!
“New modalities for challanging targets in drug discovery”
E Valeur*, SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914
Welcome, Niall and Mathias! All the best for your PhD research!
“Translocation of an intracellular protein via peptide-directed ligation”
C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013
We wish you a merry Christmas and a happy New Year!
Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.
Adrian successfully defended his PhD thesis “Kohlenwasserstoff-verbrückte Peptide mit irregulärer Sekundärstruktur für die Inhibition von Protein-Protein-Interaktionen”.
“Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis”
PM Cromm, K Wallraven, A Glas, D Bier, A Fürstner, C Ottmann, TN Grossmann*, DOI: 10.1002/cbic.201600362
Philipp successfully defended his PhD thesis “Design und Synthese Peptid-basierter Inhibitoren für Protein-Protein-Interaktionen”.
Congratulations to the Etzkorn lab and thanks for having us onboard. This communication is featured on the inside cover.
“Selective protein hyperpolarization in cell lysates using targeted dynamic nuclear polarization”
T Viennet, A Viegas, A Kuepper, S Arens, V Gelev, O Petrov, TN Grossmann, H Heise, M Etzkorn*, DOI: 10.1002/anie.201603205
This article is featured on the cover.
“Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase”
PM Cromm, J Spiegel, P Küchler, L Dietrich, J Kriegesmann, M Wendt, RS Goody, H Waldmann*, TN Grossmann*, DOI: 10.1021/acschembio.6b00386
“Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides”
PM Cromm, S Schaubach, J Spiegel, A Fürstner*, TN Grossmann*, H Waldmann*, DOI: 10.1038/ncomms11300